What Are Exosomes?

Exosomes are small vesicles released by all the cells, but especially by stem cells. They are, essentially, little messengers carrying important signaling proteins and genetic information from cell to cell. Their primary job is to act as a connection between all our cells, facilitating communication whether cells are near to one another or distant. The information they carry tells our cells to turn on or off certain functions or to react in a certain way.

Why use umbilical cord MSC exosomes?

Due to the high medical risks of using live stem cells, they have been highly regulated. Currently, the only legal way to use live stem cells is if they have been derived from the patient themselves, are not manipulated in any way, and are used as a tissue transplant. These current methods of using live stem cells have major shortcomings beyond the health risk. First, any tissue that is used as a transplant is limited in its application by only being able to be applied to similar tissue (placenta membranes may only be used on similar skin-type tissues). Second, any self-derived stem cells are subject to degradation due to aging. At the age of 40, a person’s stem cells begin to lose effectiveness. By the age of 60, the age of most patients needing stem cell treatments, the stem cells are barely effective, if at all.

We combat this by using a placenta from a newborn and extracting the mesenchymal stem cells. This allows us to use the newest and most potent stem cells possible. We then screen and culture them in a lab to control the safety and efficacy of the cells. We then immerse them in the appropriate medium, which allows them to secrete exosomes with consistent and high quantities of regenerative factors. Finally, we extract the exosomes and analyze them through batch testing, at which point they are made available for research purposes.

The use of regenerative medicine products such as BMA, PRP, Amnio, stem cells, and exosomes has skyrocketed over the last decade. While some have reported great outcomes, others have reported no effectiveness, and in worse cases, harm has come to individuals through autoimmune responses, viruses, and tumors. MSC exosomes are created in a controlled environment achieving consistent product composition through different batches and different donors. They are rigorously tested through the same batch of safety testing as used in the pharmaceutical industry.

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